Methylphenidate precursor
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Methylphenidate reference compound |
Reaction scheme |
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Comment |
Deprotection can be achieved using mercaproacetic acid/HCl-diethyl ether1 or L-cysteine/H2SO4.2 The second deprotection system avoids use of the toxic and volatile reagents. |
References |
1. Ding, Y.-S., Sugano, Y., Fowler, J. S. & Salata, C. Synthesis of the racemate and individual enantiomers of [C-11] methylphenidate for studying presynaptic dopaminergic neuron with positron emission tomography. Journal of Labelled Compounds and Radiopharmaceuticals 34 [10], 989-997 (1994). 2. Studenov, A. R. et al. An improved method for the radiosynthesis [11C]d-threo-methylphenidate. Journal of Labelled Compounds and Radiopharmaceuticals 49 [5], 455-458 (2006). |