[¹¹C]Methylphenidate (MP)

Methylphenidate precursor

Methylphenidate reference compound

Reaction scheme

Comment

Deprotection can be achieved using mercaproacetic acid/HCl-diethyl ether¹ or L-cysteine/H₂SO₄.²  The second deprotection system avoids use of the toxic and volatile reagents.

References

1.         Ding, Y.-S., Sugano, Y., Fowler, J. S. & Salata, C. Synthesis of the racemate and individual enantiomers of [C-11] methylphenidate for studying presynaptic dopaminergic neuron with positron emission tomography. Journal of Labelled Compounds and Radiopharmaceuticals 34 [10], 989-997 (1994).

2.         Studenov, A. R. et al. An improved method for the radiosynthesis [¹¹C]d-threo-methylphenidate. Journal of Labelled Compounds and Radiopharmaceuticals 49 [5], 455-458 (2006).